Prednisone and Prednisolone

These are two very similar medications that are in the glucocorticoid class of medications. Glucocorticoids are naturally occurring the body’s hormones manufactured in the the main adrenal gland called the adrenal cortex. The adrenal gland is found in the space behind the abdominal hole called the retro-peritoneum and is adjacent to the top of end of the kidney, hence its name adrenal AMOXI online.

The adrenal gland comprises the outer aspect called the cortex, and the inner part called the medulla. The cortex is primarily an endocrine gland, meaning it produces the body’s hormones that are released into the body, called corticosteroids. Cortisol is one of these corticosteroids whoever function that includes stimulating the release of sugar and carbohydrates from tissue, and is called a glucocorticoid.

Many man made and semi-synthetic medications are in the class called glucocorticoids. Two of these are prednisone and prednisolone. Prednisone is normally used as an by mouth medication. It is stronger milligram for milligram than cortisol. One mg. of prednisone has a comparable capability as 5 mg of cortisol. The adrenal gland naturally releases about 20 mg of cortisol into the system daily. In patients with adrenal insufficiency a typical daily amount of prednisone to be used for hormone replacement therapy is 5 mg daily. Prednisone is not soluble in water, and so can’t be given intravenously. Prednisone taken orally is metabolized into prednisolone by the body processes.

Prednisolone is also available as a medication. It is soluble in water, and so can be given intravenously, as well as being injected into tissue and joint spaces. Prednisolone is a popular INTRAVENOUS glucocorticoid, and is particularly sometimes given orally. It is a common by mouth preparation for children, as it is soluble and so can be wiped out in water and so changed to syrup. Prednisolone is slightly stronger on a mg. for mg. basis than prednisone. About 4 mg or prednisolone is equivalent to 4 mg of prednisone and 20 mg of cortisol.